Le Clos de Mouches is a 62-acre Premier Cru vineyard in Beaune, in Burgundy’s Cote d’Or. Though Beaune has no Grand Crus, it has 44 vineyards that are either entirely or partly Premier Cru. Le Clos de Mouches is located in the southern third of the appellation, and like many of its neighbors, it faces nearly due east.